King soopers pharmacy hours

Ciprofloxacin 500mg male uti

2023.06.09 07:40 kingofsnake96 Ciprofloxacin 500mg male uti

Hey guys I am currently in Nicaragua and came down with what I am sure Is a uti , not a nice experience ! I went to the pharmacy to ask if they had anything and they gave me 12 of these tablets and told me to take 1 every day
I took one approx 6 hours ago and feel about 30% better which is great but the side effects are freaking me out
I am super athletic and go the gym maybe 4 days a week and surf maybe 4/5 times a week also,
I am currently here on a surf trip to surf as much as possible (till my shoulders fall of as we say in our community)
I think I may take it twice more and then stop, or go back to the pharmacy tomorrow or go to a different one to see if I can get something else what you guys think thanks my
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2023.06.09 07:09 DarknTerrible [Waybound] Points Sage Blooper

In front of the Paths of Heaven, the Points Sage knelt, deep in concentration. Yerin appeared suddenly, a bright white flash. “What are you doing?”
Lindon shifted slightly. “Meditating.”
“On?”
“Sage stuff.”
Yerin tapped a finger on Netherclaw. “Didn’t realize getting answers would be like pulling a stuck sword.”
Lindon cracked his eyes, concentration broken. “I’m using the Points Icon to meditate on speedrun strats for the fight. If I can use a bunch of really big attacks all at once, and get Northstrider, Malice and Shen to do the same, I can hit an entity cram one-shot multi-kill with the Silent King Bow and then I’ll have hours to make more weapons out of them-“
Yerin cut him off with one upraised hand. “Sage stuff it is.” But Lindon would not be stopped.
“-and then in the fight the the Weeping Dragon, if you guys all jump in the Arelius portal at the exact same time and get the Oracle Sage to throw a rock in, you’ll have no-clip and can phase through the Dragon’s Breath and attack the Dragon while he can’t hit you-“
A blue flash erupted across the pocket world as space tore open, revealing Eithan in black armor. Lindon jumped to his feet fast enough to crack the ground. “Quick, Lindon! I’m about to fight the Mad King, use the Points Icon to tell me the loot table!” Lindon dropped back to his knees, screwing his eyes shut and blocking out whatever Eithan and Yerin were saying. The loot table came to him in a flash… an empty flash.
“It doesn’t look like he drops anything!”
A voice like cracking space and extinction crackled through Ghostwind Hall, carrying the unmistakable tones of pure disbelief. “What do you mean I don’t drop anything? I’m a space king on a murder spree whose exploits span multiple millennia! Does Oth’kimeth drop something?” Lindon checked.
“Nope.”
The Mad King’s red sun eyes stared at Lindon, looking lost. “But… we’re like…super big villains! We conquer worlds! I have a cool backstory where I used to be the last Executor, and then locked Oth’kimeth inside myself, and then got thrown in Haven and escaped…”
“Apologies, but I don’t know what to tell you.”
Eithan raised a hand, waited for two slow seconds, and clapped the Mad King awkwardly on the back. The Mad King braced his hands on a portion of space that solidified under his bone gauntleted hands, staring into the distance. “We could still have a cool final battle?” Eithan suggested. Daruman pulled off his helm, looking smaller than he had a moment ago. “Maybe tomorrow.” With another blue flash, the portal closed.
Yerin looked at Lindon, looked at the empty space where Eithan and the Mad King had stood, then back at Lindon, before shrugging and teleporting away.
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2023.06.09 07:09 SvenExChao Spouse refuses to go back on medication

My spouse had insurance pull coverage for their medications early this year and have been off their meds for months and since then things have gone exactly as you’d all expect. I found a manufacturer’s savings card that could be the problem solver we need, but even though they’ve promised to go to the pharmacy day after day they don’t.
I’m past my limit, I absolutely love them and want them to get the meds they need and for it all to work out. I’ve started asking once a day, only once. Today they said they’d go and then went and slept for hours until we had dinner plans with friends. I woke them up and asked “are you still going today?” And they said yes but then didn’t. So after our plans I said “if you haven’t gone to the pharmacy by my lunch break I’m driving you myself” and that kicked off a whole stomping door slamming rage session. My only hope right now is that these lashing out episodes always are followed by depression and in depression they have to face the fact that they have an illness. It’s been months and I’m beyond exhausted.
I just don’t know what to do. I feel the only option left for me is filing for separation with the understanding that I’m completely willing and want to end the separation on the condition that they work with their doctor and take the prescribed medications. But even that has a 3 month waiting period. I just feel stuck. Does anyone have advice for talking to someone who’s off their meds about getting back on that’ll be more effective? I’m willing to try anything if it means getting my partner back.
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2023.06.09 06:52 AutoModerator [Genkicourses.site] [Get] RY Schwartz – Coaching The Conversion CTC Circle (10/2022) - Full Course Download

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breaking down every single phase of your launch or funnel in full detail (including some you didn’t even know existed). You’ll learn exactly what’s at play during the Segmentation & Confirmation, Pre-Launch, Launch, Sales and Closing phases of your funnel and how to quickly craft the messaging that coaches your prospect into the final conversion in a powerful, non-sleazy way.

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It’s your long-form sales page.
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Courses proof (screenshots for example, or 1 free sample video from the course) are available upon demand, simply Contact us here
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2023.06.09 06:22 anonymous-shad0w In Walgreens Latest Divestiture, Drugstore Chain Sells Remaining Stake In Infusion Business

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2023.06.09 06:21 sadnesslaughs Though the Demon King likes to think of himself as evil, his idea of evil is.... PG-13, for the lack of a better word. Compared to the medieval atrocities of the previous human kings, it's one hell of an improvement.

“You dare steal from the king, peasant?” The Demon King screeched, flames erupting from the empty eye sockets of the skulls on his throne. He pulled himself to his feet. The King digging his boney fingers into the empty eye sockets, pulling himself up. “I guess I need to make an example of you. How is our castle wall looking today, Xea?”
The buff demonic guard crossed her arms, pretending to think about the condition of the wall. After a minute of tossing her from head side to side, she grinned, showing those dangerously sharp teeth.
“I believe the castle wall is spotless. Not a cloud in the sky, either. The peasants will get a good view of the torment you’re going to put this man through. Will I make the arrangements, my lord?”
“Please, please no. I needed food for my family. I wasn’t about going to steal anything other than food. Please. They need me.”
“Oh, they need you? Did you hear that, Xea? His family needs him. Gather his family then.”
“As you instruct, my lord. I will make sure they join him.”
The man’s face went pale, falling to his knees. The strength in his body getting sapped by the news that his family would join him on the wall. His head hit against the hard stone floor, sobbing at the feet of the Demon King, who appeared unmoved.
“Take the idiot with you, too. He’s getting my floor dirty.”
A few hours passed, and they gathered the family on top of the castle walls. The peasants down below didn’t appear too frightened. Only looking on in confusion, never having seen the king make such a spectacle like this. Had their luck run out? Perhaps the Demon king was going to put them on pikes like the previous king had done? Leaving them to rot in the sun as a message to all the other villagers.
“Greetings, my lowly boot lickers. Today, I caught one of your villagers stealing from me. Not only is this an offence against me, it’s also an offence against my guard’s honor. Poor Xea, felt horrible knowing a human snuck past our defences, didn’t you, Xea?”
“Oh, I did. The shame’s awful, only their screams will make me feel better. So, my lord? Will you please do the honors of making me feel a little better?” Xea asked, putting her hand on the father’s shoulder, glaring at the family. “I don’t enjoy being embarrassed.” Her grip got a little tighter, pushing against his joint, threatening to pop it. “Just kidding.” She said, releasing it.
“Of course, I treat my soldiers with kindness and my thieves with a glimpse of hell. Ready to witness hell?” The Demon King walked towards the edge of the wall, holding his arms up.
“WAIT, PLEASE NOT MY FAMILY. KILL ME, KILL ME AND LET THEM LIVE.” The man went back to sobbing, even though his family appeared to be taking the chaos rather well. Even the smallest of the children didn’t appear scared. Instead, she reached over and gave her father a pat on the back.
“It’s ok. Mr. Demon isn’t bad. He’s just confused. That’s what the villagers said.” She whispered.
Xea rolled her eyes when she overheard that. Her pointed ears twitching as she crouched behind the pair, putting her face between the two. “Whatcha talking about? Care to share that with me? I hope you weren’t talking about my glorious leader.”
That shut the pair up, as they went back to looking at the village. The Demon King raised his arms, and the Earth began rattling. The ground shaking as though hundreds of imps would soon burst from the soil. Villagers were getting nervous now, rushing to make sure their cattle were secure as things shook around them.
When the king lowered his arms, the ground stopped shaking, leaving everyone bewildered. Had he done something? A villager stepped onto his farming land, getting smashed onto his back by a barrage of carrots. The carrots shooting from the soil, littering the land. All the farms shared a similar fate, harvests sprouting all around them.
“Hahahaha. Now you will have all the food you want. Good luck getting rid of all those rotting vegetables. How will you deal with all the dangers that come with that?”
“Excellent work, my king.” Xea clapped, even if she missed her usual role of torturing souls in hell. Something about doing acts like this was fun to her. Did she just enjoy scaring the peasants before the deception revealed itself? Enjoying that moment of utter fear they felt in their souls?
“Wait. I don’t get it?” The man said, wiping his eyes. “Isn’t this a good-“
“HERALD. Shut up!” His wife hissed, giving him a small smack on the back of the head.
The villagers all fell to the ground, acting as though an invisible arrow had struck them all in the knee. Some rubbed dirt on their faces to look more pitiful, while others pretended to cry.
“SAVE US GOD. This foul man has cursed us.” One wept.
“How evil can you be?” another called out.
“Hey John, can I borrow your hoe?” One whispered, using this time to ask for a favor.
The Demon King turned away, walking back to his throne room. “Xea, mind throwing them back into the village for me? I’m bored now.”
“Certainly, my lord.” Xea raised her hand, shooting a wave of air at the family, sending them hurtling over the side of the wall. Just as they were about to hit the ground, they stopped. Being gently put onto the floor with Xea’s abilities.
“Again! Again!” The little girl cheered, looking up at the demonic guard who was peering over the wall.
“Shush dear. You weren’t meant to enjoy it.” The mother said, covering her child’s mouth. She couldn’t help but smile at Xea. For such an intimidating demon, she appeared to be a big softie, too.
“I don’t get it. What they did was a good act? Shouldn’t they have put my head on a spike or got a bunch of horses to run over my body?” Herald said, scratching his head.
“You’re new here, right? We should have told you this earlier. The demon kings a little backwards in his ruling. He thinks he is doing evil acts, but most of the times he’s giving us a smack on the forehead or something equally soft. This is the first time in a while he’s done a good act.” The villager explained.
“So, he’s a good ruler?”
“Yes, don’t let him know that, though. I wouldn’t want him to copy our last king.”
“That guard of his was kind to let us down. Maybe I’ll bake her something. Do you think she likes cakes?” Herald’s wife asked, putting an arm around her husband.
Meanwhile, Xea was licking her lips as she went to the throne room, hoping she was going to get that cake that was promised. When she got to the throne room, she bowed before the Demon King.
“Sir, you know you’re doing righteous acts, correct?”
“Do you think I’m an idiot? I know what I’m doing is good. I was the king of hell.”
“May I ask why you are choosing to rule like this, then?”
“Boredom, mainly. I came to Earth fully prepared to put this village through hell. I had all these ideas that would make them suffer. Then I saw the previous kings, each one a waste of humanity’s potential. All these people knew was horror. What more could I do to a world already filled with hate and bloodshed? So, I’m going to give them two hundred years of peace. Then let them handle whatever comes after that.”
“I see, so you plan to get their hopes up, only to let humanity bring itself down again when you leave. You would get to see their torment without even having to lift a finger. You could watch it all happen from hell. That’s so devilish, my king.”
“It is. Though, I will admit. I’m not disliking my time being gentle. Even a king of hell enjoys some change in his life. We have both spent hundreds of years tormenting souls. We should enjoy our vacation.”
“Are you suggesting I treat this as a vacation?”
“I’m suggesting you allow yourself to interact with the villagers. Befriend them, join in their festivities. Enjoy seeing humanity at its best, before it all comes crashing down.”
“I’ll do that, sir. Thank you.”
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2023.06.09 06:17 Secure_Midnight_6708 New Video

New Video submitted by Secure_Midnight_6708 to arma [link] [comments]


2023.06.09 06:13 13ig13oss Cardinal Nuclear pharmacist job interview tips?

Hello, I'm a new grad and I have an interview for nuclear RPh at cardinal and I was looking for any tips. I did a rotation at an independent so I know the hours are ugly which I don't mind at all but I'm looking for anything to help me land the position. And what would be a reasonable start pay? I've been a lead tech/rph intern at a LTC for five years full time through pharmacy school.
submitted by 13ig13oss to pharmacy [link] [comments]


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2023.06.09 05:53 Lunar_Husk Terraria Events vs Skyrim Holds

Based on a previous post of mine, but with the rise in talk of Skyrim, I wonder how well the Skyrim Holds would be able to fair against these dangerous events.
Rules:
Events (In Order):
Rounds:
  1. The Holds are held by the Empire with no outside help.
  2. The Holds are held by the Stormcloaks with no outside help.
  3. The Holds are held by the Empire with outside help allowed (if they can get it).
  4. The Holds are held by the Stormcloaks with outside help allowed (if they can get it).
  5. Dawnstar, Falkreath, Morthal, Ravenrock, and Winterhold all must defend themselves from the invasions alone.
Win Conditions:
Terraria Events; Kill the Jarl, the majority of citizens, destroying most of the Hold.
Skyrim Holds; Push back against all Events.
submitted by Lunar_Husk to whowouldwin [link] [comments]


2023.06.09 05:52 AutoModerator [Genkicourses.site] [Get] RY Schwartz – Coaching The Conversion CTC Circle (10/2022) - Full Course Download

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CTC Launches

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10X Launches is the first copywriting program fully engineered to speed up the execution and amplify your results of your emails no matter what kind of funnel or launch strategy you’re rolling out.
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2 “Core” Modules

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5 “Launch” Modules

breaking down every single phase of your launch or funnel in full detail (including some you didn’t even know existed). You’ll learn exactly what’s at play during the Segmentation & Confirmation, Pre-Launch, Launch, Sales and Closing phases of your funnel and how to quickly craft the messaging that coaches your prospect into the final conversion in a powerful, non-sleazy way.

25+ Email Templates

None of that BS “plug’n’play” or “swipe and deploy” stuff that shoehorns your message into lifeless boxes that robs it of all life and power.
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Meaning, you get to craft your OWN high-converting launch emails in about 25 minutes flat and fire them into ConvertKit, ActiveCampaign (or wtv you’re using) while your coffee’s still hot.

Program #2

CTC Sales Pages

(to master your long form sales page)
This is it.
It’s where the best paid copywriters, coaches and course marketers on the planet earn their keep.
It’s where the conversion either happens or it doesn’t. In cold hard numbers that don’t care how many Clif bars you stress-ate in the process.
It’s where the most admired online business owners transform interest, desire, and engagement and into what you actually want: Sales.
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It’s your long-form sales page.
And the truth is… most copywriters and marketers avoid long-form sales pages like the plague… treating it like a close-talking lepper with coffee breath… instead of the 24/7 salesperson your sales page – that final step in your marketing funnel – should be.
So why do marketers (and even pro-level copywriters) avoid sales pages?
Because writing a long-form sales page is intimidating AF.
It’s the Night King of the Whitewalker army.
It’s the Beef Wellington on Hell’s Kitchen.
It’s the Lord Voldemort of your marketing funnel – aka the funnel asset that shall not be named.
A long-form sales page is where you’ll spend dozens of hours writing THOUSANDS of words that will either confirm your claim as a top player in your space…
Or will tell you with Gordon-Ramsay-esque candor that your marketing wasn’t as good as your business coach told you it was.
There’s real pressure in that.
But there’s even real-er payoff in being able to do it faster – and more profitably – than anyone else in your industry. A payoff that even affords you the right to make up words like real-er
Confronting, yep? Conquerable. Absolutely.
In CTC Sales Pages, you’ll go through the exact process I’ve used to write over twenty 6 and 7-figure sales pages for the likes of Amy Porterfield, Copyhackers, and many more.

Program #3 & #4

Six Figure Emails & Seven Figure Emails

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Welcome to the “Johnnie Walker Blue” of our email template series.
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What you’re getting are 13 advanced email templates that you can use in a pinch when you need to write a standalone sales email, a webinar invitation, a post-webinar replay, downsell, or flash sale.
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These are loose, flexible templates that guide you through deep-dive masterclasses teaching you the advanced psychology behind each one.
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Minimum Viable Launch 2.0

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Application Funnel Amplifiers

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Fact: The enrollment experience begins the moment your prospect books a call.
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In this brand new program, you’ll learn how we to consciously engineering your entire application experience to pre-empt objections, create magnetism, and stack the odds in favor of having a successful enrollment conversation
You’ll get practical answers to:
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  • How to strategically structure your application questions in a way that actually coaches your pre-customer into your program (yes, the questions are copy)
  • What to put on your booking confirmation page to create incredible momentum and a “point of no return” into your program
  • What tools and systems we use to create a seamless application and booking experience

Program #7

Next-Level Automation & Optimization Stack

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As the CTC Membership evolves, our resident Wizard, Philip Powis will be actively adding a library of importable one-click automations (into ActiveCampaign), leveraged software playbooks, and a running list of the most advanced (and cost effective) tools and systems that he recommends for fast-scaling course and coaching businesses.

Courses proof (screenshots for example, or 1 free sample video from the course) are available upon demand, simply Contact us here
submitted by AutoModerator to Genkicourses_Com [link] [comments]


2023.06.09 05:46 recentlyquitsmoking2 Hitchens on Pat Robertson

“As the year 2000 approaches, it is a safe bet that we will be treated to more superstition and barbarism of the [Pat] Robertson sort, and that other unscrupulous demagogues will try to canalize the fears and doubts of those who have been let down by the education system.” [“Minority Report,” Nation, 10/04/86]
“Whether you are a creationist like Pat Robertson, or a Catholic like Pat Buchanan, or a materialist believer in ‘Natural Law’ like [Harry] Jaffa and others, you can’t avoid the salient fact that the Creator, or the Divinity, or Nature, or Evolution, has evidently mandated that there be a certain quite large number of homosexuals.” [“Bloom’s Way,” Nation, 5/15/00]
"The disappointment was, and to me remains, acute. Within hours, the “reverends” Pat Robertson and Jerry Falwell had announced that the immolation of their fellow creatures was a divine judgment on a secular society that tolerated homosexuality and abortion. At the solemn memorial service for the victims, held in the beautiful National Cathedral in Washington, an address was permitted from Billy Graham, a man whose record of opportunism and anti-Semitism is in itself a minor national disgrace. His absurd sermon made the claim that all the dead were now in paradise and would not return to us even if they could. I say absurd because it is impossible even in the most lenient terms to believe that a good number of sinful citizens had not been murdered by al-Qaeda that day. And there is no reason to believe that Billy Graham knew the current whereabouts of their souls, let alone their posthumous desires. But there was also something sinister in hearing detailed claims to knowledge of paradise, of the sort that bin Laden himself was making on behalf of the assassins." - God Is Not Great
"The suspicion that a calamity might also be a punishment is further useful in that it allows an infinity of speculation. After New Orleans, which suffered from a lethal combination of being built below sea level and neglected by the Bush administration, I learned from a senior rabbi in Israel that it was revenge for the evacuation of Jewish settlers from the Gaza Strip, and from the mayor of New Orleans (who had not performed his own job with exceptional prowess) that it was god’s verdict on the invasion of Iraq. You can nominate your own favorite sin here, as did the “reverends” Pat Robertson and Jerry Falwell after the immolation of the World Trade Center. In that instance, the proximate cause was to be sought and found in America’s surrender to homosexuality and abortion. (Some ancient Egyptians believed that sodomy was the cause of earthquakes: I expect this interpretation to revive with especial force when the San Andreas Fault next gives a shudder under the Gomorrah of San Francisco.) When the debris had eventually settled on Ground Zero, it was found that two pieces of mangled girder still stood in the shape of a cross, and much wondering comment resulted. Since all architecture has always involved crossbeams, it would be surprising only if such a feature did not emerge. I admit that I would have been impressed if the wreckage had formed itself into a Star of David or a star and crescent, but there is no record of this ever having occurred anywhere, even in places where local people might be impressed by it. And remember, miracles are supposed to occur at the behest of a being who is omnipotent as well as omniscient and omnipresent. One might hope for more magnificent performances than ever seem to occur." - God Is Not Great
"The same can be said of the King epoch. The southern churches returned to their old ways after Reconstruction, and blessed the new institutions of segregation and discrimination. It was not until after the Second World War and the spread of decolonization and human rights that the cry for emancipation was raised again. In response, it was again very forcefully asserted (on American soil, in the second half of the twentieth century) that the discrepant descendants of Noah were not intended by god to be mixed. This barbaric stupidity had real-world consequences. The late Senator Eugene McCarthy told me that he had once urged Senator Pat Robertson—father of the present television prophet—to support some mild civil rights legislation. “I’d sure like to help the colored,” came the response, “but the Bible says I can’t.” The entire self-definition of “the South” was that it was white, and Christian. This is exactly what gave Dr. King his moral leverage, because he could outpreach the rednecks. But the heavy burden would never have been laid upon him if religiosity had not been so deeply entrenched to begin with. As Taylor Branch shows, many of King’s inner circle and entourage were secular Communists and socialists who had been manuring the ground for a civil rights movement for several decades and helping train brave volunteers like Mrs. Rosa Parks for a careful strategy of mass civil disobedience, and these “atheistic” associations were to be used against King all the time, especially from the pulpit. Indeed, one result of his campaign was to generate the “backlash” of white right-wing Christianity which is still such a potent force below the Mason-Dixon line." - God Is Not Great
"The Leader of the Free World was frequently photographed in the company of “end-times” Protestant fundamentalists and biblical literalists like Jerry Falwell and Pat Robertson: tethered gas-balloons of greed and cynicism once written up by Martin Amis as “frauds of Chaucerian proportions.” The president found time to burble with such characters about the fulfillment of ancient “prophecy” and the coming Apocalypse. He also speculated drivellingly that the jury might yet return an open verdict on the theory of evolution. He was married to a woman who employed a White House astrologer. He said that the Abraham Lincoln Battalion had fought on “the wrong side” in the civil war in Spain, which logically meant that there had been a “right” side and that it was the Francoist one. (When the last attempt at a fascist coup was made in Spain, in the early 1980s, the Reagan administration was asked for comment, again in the person of the Strangelovian freak Alexander Haig, who flabbergastingly said that the armed attack on Spain’s elected parliament was a purely internal Spanish affair.) With Haig, Reagan also gave permission to Menachem Begin and Ariel Sharon to invade Lebanon in 1982, and to take their incursion as far as Beirut to do the dirty work of the Catholic Phalange. In order to gratify Chancellor Helmut Kohl of West Germany, Reagan agreed to visit an SS cemetery in Bitburg (Ich bin ein Bitburger) and, as if that in itself was not bad enough, to declare that those interred there were not just “victims,” but victims “just as much” as the civilians they had slaughtered. He made stupid, alarming on-air jokes about pre-emptively bombing the USSR. He pardoned the convicted FBI agents Felt and Miller, who had been prosecuted and fired for illegal break-ins and wiretaps directed at the anti-war movement. In a really sweet irony, one of these men (Mark Felt), as I was to learn, had been the “Deep Throat” whose torpedoes had sent the previous elected Republican administration to the floor of the sea.*" - Hitch-22
submitted by recentlyquitsmoking2 to ChristopherHitchens [link] [comments]


2023.06.09 05:40 konsyr Grim Dawn Version v1.1.9.8

On the forums.
Previous patch.
As the gods have foretold, another patch walks among us.
We hope you enjoy the latest bug fixes and balance changes. Stay tuned for the next one!
V1.1.9.8
[Crucible]
[Shattered Realm]
[Animation]
[Tech]
[Game]
[Itemization]
Faction Items
Relics
Monster Infrequents
Epic Items
Legendary Non-Set Items
Legendary Set Items
See comment below.
[Class & Skills]
Devotion
Demolitionist
Occultist
Nightblade
Arcanist
Shaman
Necromancer
Oathkeeper
submitted by konsyr to Grimdawn [link] [comments]


2023.06.09 05:17 Thaboss72 Antibiotics following Vasectomy

Wife got me a hotel to lay up in following my vasectomy today so I didn’t have to worry about the kids. Had the no scalpel about 6 hours ago, the nurse at the end told me that some antibiotics had been sent to the pharmacy. I’ve had a few sinus infections over the last four months that required Me to take antibiotics. I really don’t want to take anymore, question is, how many people were not prescribed antibiotics?
submitted by Thaboss72 to Vasectomy [link] [comments]


2023.06.09 05:02 AutoModerator I HAVE Iman Gadzhi Agency Navigator, Biaheza Dropshipping Course, Andrew Tate all Courses Bundle, And OVER 3,000 MORE COURSES. If ANYONE WANTS them (http://smmacourses.site/)

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2023.06.09 04:53 TheAJAlmighty how long should I feel effects of Adderall XR?

Recently prescribed adderall xr as my first med for ADHD. 10 mg. I’ve been taking about a week now and it takes about an hour to feel something and that feeling is very mild and lasts about an hour maybe slightly more then I’m probably worse than I was before (probably psychologically upset that I know long feel benefits)
I assume my dose is too low, but once I hit the right dose, how long should I be feeling the effects?
Also, if I was given a 30 days script of 10mg and my next follow up is this coming week and she ups my dosage, will the pharmacy fill a NEW script before 30 days?
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2023.06.09 04:52 monkeywarrior333 Questions about trying to find the squid in FOMT

So I'm starting to look for the squid(as well as all the other king fish) but I keep running into conflicting info. My main problem is season: I've seen some websites say you can catch it in any season except winter, and some that say only winter.
Aside from that, there are a couple smaller questions. With that being, I wanted to ask the following: 1. What season do you catch the squid in?
  1. The wiki says you just need to drop a "smaller fish", but multiples forums have said that it's strictly small fish. Which is it?
  2. Do you have drop in a new fish every time you fish for the squid, or does it just reset by maybe the day or by exiting the beach?
  3. How many in game hours or days would usually be expected to catch the squid? I had a pretty easy time catching the jp. huchen and carp, but lots of the forums I previously went to indicate that the squid might take the longest out of the king fish to catch.
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2023.06.09 04:52 Pleasant-Talk1097 Spinal stenosis, arthritis, bulging discs in 2022 MRI. I couldn’t walk weeks before an epidural injection and now, 8 days afterward, I still can’t walk.

The pain doctor I’m seeing and the employees aren’t treating my condition like I’m in massive excruciating pain. They told me on Wednesday that I need another MRI and surgery. I was referred me to another spine doc that’s a surgeon. I’ve heard nothing since then. I’ve left messages and gotten nothing back. Then, A floater pharmacist at the CVS pharmacy I work at as a tech told me if I get another pain med filled, no pharmacist will fill me ever again. What can I do? Can I just go to the ER, ask for an MRI, and get surgery? I asked for the injection 2 months ago. I quit being able to walk about 3 and a half weeks ago. The clinic and Aetna dragged their feet on the prior auth and literally everything else. I’ve been in the worst pain of my life, worse than contractions from labor. I’ve gone to the er twice, they just give me pain meds and send me away. This whole experience has been pathetic. I’m in so much pain, I keep wanting to go to the er and the internet says I should go. I can’t put weight on that leg, but every effing time, they just give me pain meds and after a couple hours send me back home. I can’t stand it anymore, I can’t do this anymore. Can I just go to a hospital and refuse to leave til they give me an MRI and schedule surgery? This is the most ridiculous process I’ve ever endured. I’ll pay out of pocket for the MRI, I’ll get on a payment plan for the surgery, I don’t care anymore and need to just get this done asap. What do I do? I literally can’t walk without someone holding me and a cane for weeks now and my SO needs to go back to work. I don’t know if this info is necessary but, the pain doctor said I probably need a Diskectomy.
So…
  1. How do I get this MRI and surgery asap? 1A. Do I HAVE to wait on the pain clinic and prior auth?
  2. In the meantime until surgery and for the recovery period, will I get cut off from pain meds? 2A. If so, what do I do in that case?
  3. What do I do when it’s unbearable?
submitted by Pleasant-Talk1097 to AskDocs [link] [comments]


2023.06.09 04:52 AutoModerator [Genkicourses.site] [Get] RY Schwartz – Coaching The Conversion CTC Circle (10/2022) - Full Course Download

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breaking down every single phase of your launch or funnel in full detail (including some you didn’t even know existed). You’ll learn exactly what’s at play during the Segmentation & Confirmation, Pre-Launch, Launch, Sales and Closing phases of your funnel and how to quickly craft the messaging that coaches your prospect into the final conversion in a powerful, non-sleazy way.

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This is it.
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In CTC Sales Pages, you’ll go through the exact process I’ve used to write over twenty 6 and 7-figure sales pages for the likes of Amy Porterfield, Copyhackers, and many more.

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Welcome to the “Johnnie Walker Blue” of our email template series.
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Fact: The enrollment experience begins the moment your prospect books a call.
If you mail it in for those 12-72 hours between when they book the call — and show up to it, you’re missing a golden opportunity to begin coaching the necessary transformations.
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You’ll get practical answers to:
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  • How to strategically structure your application questions in a way that actually coaches your pre-customer into your program (yes, the questions are copy)
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As the CTC Membership evolves, our resident Wizard, Philip Powis will be actively adding a library of importable one-click automations (into ActiveCampaign), leveraged software playbooks, and a running list of the most advanced (and cost effective) tools and systems that he recommends for fast-scaling course and coaching businesses.

Courses proof (screenshots for example, or 1 free sample video from the course) are available upon demand, simply Contact us here
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2023.06.09 04:29 Bubzoluck [30 min read] The Opioid Epidemic before the Opioid Epidemic - Exploring Morphine Derivatives and the First Opium War (Part 1)

[30 min read] The Opioid Epidemic before the Opioid Epidemic - Exploring Morphine Derivatives and the First Opium War (Part 1)
Hello and welcome back to SAR! I have written and rewritten this post a few times now and I think I have landed on a format I am happy with. When we talk about the impact of medicine on history its important to get the context right, and I think I have found a way to talk about our topic. So what is it? No chemical is more important to the world of medicine than Opium, okay maybe Penicillin, but today we will say its Opium. Principally an analgesic (anti-pain), the Opium Poppy allowed for humans to take away pain in great degrees and further development on the natural chemicals has opened up surgery and post-op recovery. While we tend to look at the recent Opioid Epidemic as the only issue regarding Opiates, history reveals to us a very similar precursor. Also please head over to u/jtjdp post about morphine derivatives here! She does an amazing job explaining the higher level concepts of medicinal chemistry that I just wouldn’t do justice. Alright, enough quibbling, let’s get to the good stuff.
Disclaimer: this post is not designed to be medical advice. It is merely a look at the chemistry of medications and their general effect on the body. Each person responds differently to therapy. Please talk to your doctor about starting, stopping, or changing medical treatment.

How Much do you Know About Pain?

To be alive is to feel pain, and emo sentiments aside, this is one of the biggest biological properties of the central nervous system. When you think about it, how does the body take external stimuli and allow you to recognize it? The answer is the sensory nervous system which is responsible for sensing many different types of stimuli: temperature, pressure, pain, and chemicals. These sensory neurons carry the information from the extremities and transmit it up the spinal cord into the brain for processing. From there the brain alerts you to the issue allowing you to correct whatever problem is causing the pain. Let’s take a look:

https://preview.redd.it/36yiuubbjw4b1.png?width=660&format=png&auto=webp&s=a8dc870ed6d879d67dce1eb126b86ba5acb9bc69
  • We call these receptors Nociceptors and activation of these neurons in the periphery leads to a signal being sent towards the spinal cord. Those peripheral nerves eventually complex with the Dorsal Horn of the spinal cord and interface with the central nervous system to transfer the pain signal. This signal is then sent Ascending to the Thalamus where the pain signal is recognized and initiates a response (such as pulling your hand away from the hot stove). But that’s not the full story, the brain also sends signals back down Descending to modify the incoming signal and dampen it. Its this modifying that makes pain fade over time when you aren’t focusing on it—otherwise the brain would be overwhelmed by the repetitive signal and continuously think injury is still happening. Now let’s divide this process into its two parts, first up the Ascending pathway.

https://preview.redd.it/w6751owcjw4b1.png?width=896&format=png&auto=webp&s=122f8b2c615f741d848ed0171a574b1353a34038
  • As the Action Potential travels from the periphery towards the Spine it causes the influx of Calcium into the Presynaptic Neuron. This neuron is what carries the original signal to then transfer into the Spine for further traveling. Eventually we reach the Synapse where the finger-nerve and spine meet and we get the transfer of information via Neurotransmitters. In this case, two chemicals are released: Glutamate and Substance P (which literally stands for Substance Pain). Glutamate will activate two receptors (AMPA and NMDA) which are Excitatory and stimulate the continuation of the pain signal up to the brain. Substance P activates the NK1 receptor which enhances the frequency of the pain signal (the throbbing) and the intensity of the pain burst. So to simplify, Glutamate allows the signal to be passed up to the brain but depending on the strength of the original pain signal more or less Substance P is released which modulates the strength and attention-grabbing nature of it. Okay great, we sent the pain pathway up and it will get processed in multiple different parts of the brain. But the brain can’t have that signal stinging it so it must send information back down to dampen that pain signal. This is where that aforementioned Descending pathway comes in. Above you can see how the blue line reaches down out of the brain and back into the spine to turn ‘off’ the signal. This is the basis of Analgesia or pain relief.

https://preview.redd.it/audgj8kfjw4b1.png?width=668&format=png&auto=webp&s=c3b58c520e8298e20f787d70e053948c3817c565
  • Okay so now we have to divide the action of the Descending pathway which acts to dampen and modulate the original signal coming into the brain. Now, normally at rest this Descending neuron is inhibited so any fresh incoming signal is not inhibited from the get go but once that pain signal does come in, we get the good stuff! In response to pain the brain releases substances called Endorphins which activate the mu Opioid Receptor (MOR) located on the Descending pathway. Now MOR are inhibitory in nature so they are inhibiting the inhibitory resting state of neurons, or in other words, are allowing the Descending neuron to activate. And this is an important fact to recognize, Opiates do not inhibit pain, they inhibit the physiology of the nervous system that prevents modulation of the pain signal.
    • Once the inhibition is inhibited, the Descending neuron is free to release two neurotransmitters onto the nerve that was carrying the original pain signal. Both Norepinephrine and Serotonin are released to activate their respective receptors which inhibit the release of Substance P and Glutamate thus decreasing the incoming pain signal. Likewise MOR receptors are found directly on the incoming nerve and further prevent the release of Glutamate and Substance P as well as being found on the Ascending neuron preventing the activation of the NMDA/AMPA and NK1 receptors. The result: dampened incoming signal and decreased pain sense being sent to the brain.

The Stars Align in the Shape of a Poppy


https://preview.redd.it/nfygsi0hjw4b1.png?width=731&format=png&auto=webp&s=60c0b13cdad3d7b7b64f78d6294465f081839f61
To start our story about Opiates we need to turn to the great precursor—Opium. Opium itself is not a chemical but rather a really thick liquor (called latex) that contains a high concentration of Morphine (and some Codeine). There are 38 species of Poppy plants but only two produce Opium is great enough supply that it is worth farming them and humans have been cultivating these varieties for as long as we have known about the plants. When humans settled into Mesopotamia (near modern day Iraq), Poppies were one of the few plants grown in plots as large grain or vegetable fields (meaning that they were thought of as valuable as food). Throughout the Greek age of medicine (pre-500 BCE) through the Islamic medicinal revolution (500 BC-1500 AD), Opium was a major component of treatment, assisted suicide, and poison. In fact its through the rise of the Muslim Caliphates that we see the export of Opium to other parts of the world, especially through the Mediterranean Sea once the Crusaders return. Opium trading to the East via the silk roads was an almost continuous affair since time immemorial and Pakistan was a major growing area for the Eastern Poppy trade.
  • By the time after the Crusades (11-13th centuries), we start to see the West’s fixation on Opium. For many reasons Europe didn’t develop many psychoactive plants to the same degree as more humid/hot climates like Africa, the Middle East, and India. This is why the importation of Opium (and also Marijuana) was such a trade commodity and staple in the development of Western medicine. During the Renaissance and the revival of Greek philosophy we start to see the re-fascination with Opium and by the 1600s we see merchants importing Laudanum into Europe for recreational and medicinal use. The standard use of Tincture of Opium (which is Opium dissolved in ethanol, a DEADLY combination) was a particularly favorite preparation which was prescribed to the lowest day-worker all the way up to kings.
    • The importation and use of Opium exploded in the late 1700s once the British conquered a major Poppy growing region of India. This region (western India and most of Pakistan) was originally slated to grow cotton like the American colonies but the region wasn’t wet enough to sustain the plant—it could however grow copious fields of Poppy plants to create Opium. Throughout the 18th century the British Raj became the largest exporter of Opium to Europe and after the discovery that Mercury and Arsenic may not be safe, Opium took over their duties. By 1780 almost all major remedies incorporated the use of Opium in some capacity and with the huge supply, it was incredibly cheap.

https://preview.redd.it/1cspu1ukjw4b1.png?width=578&format=png&auto=webp&s=4e81b6d401a1806f39592e802b0bd5ab6df9a2e8
  • Poppy wasn’t only important to the British for its medicinal properties but also to bolster the huge amount of loss they were incurring in global trade to one trade partner—China. After she made contact with China in the mid-1500s, Britain starting to import HUGE amounts of tea as the Brits became literally addicted to the substance. By 1800 a full 15% of the ENTIRE British Empire’s revenue was being spent on importing tea, that’s 30 million pounds per YEAR, leading to a massive trade deficit. This means that more money was being sent to China literally enriching a foreign country while the British public was getting their fix on the black stuff. Oh and just in case you think things haven’t changed, Britain still accounts for 42.6% of the world’s tea consumption—seriously Brits, ever heard of coffee? Anyways, all this money leaving the British economy to be spent on non-Empire sustaining commodities was a major national security risk for the British. It would be different if they were importing gunpowder like the Dutch were or Silver as the Spanish had but literally they were consuming the riches they were spending the money on.
    • Remember too that the British were not in the best position by the turn of the 19th century—they had just lost their colonies in the Americas, involvement in the Napoleonic Wars killed a generation of men, and the push to develop industries over public health led to a focus on fast growth rather than smart growth. One of the results of the Napoleonic Wars was the British occupation of the Island of Java which developed a very potent Opium which was traded with Chinese merchants regularly. Soon British merchants realized they could rebalance the trade deficit by selling Javanese Opium into China but the small island was unable to produce enough Poppies to meet the demand. So Britain turned to another one of its colonies, India.

https://preview.redd.it/iiu2j8emjw4b1.png?width=707&format=png&auto=webp&s=d6f54a00fe47739db6545be913c186e4560195d4
  • India by the end of the 1700s was a bit of a challenge. The British hold on the subcontinent was firm but they couldn’t grow the cash crops they wanted. Indian cotton was nothing compared to Egyptian or Southern American (i.e. Virginia/North Carolina/Georgia) cotton and the Indian tobacco was known for being bitter. But by the 1770s the British government realized that Poppy was an easy crop to grow and the demand across the border with China was an easy market; British traders brought their cargo to small islands off the coast of China where it was sold for silver. Initially the Chinese didn’t mind the sale of Opium in their territory—when the British traders collected the silver from the sale they would almost immediately use it to buy Chinese goods, thus driving tax revenue for the Chinese government.

https://preview.redd.it/andjwt0qjw4b1.png?width=644&format=png&auto=webp&s=730782fa74a65c111a62f05024445656b81f9811
  • But if you buy Opium, people are going to use that Opium. By the 1810s all trade with foreigners was restricted to just one port, Canton, and slowly the city started to develop a habit for the drug. The use of mind altering substances was curtailed pretty quickly for hundreds of years in China—the Ming Dynasty banned tobacco in 1640 and the Qing banned Madak (a powdered Opium containing tobacco) was similarly banned in 1729. But by 1790 more and more Chinese citizens were becoming addicted to the substance; what started as a recreational drug slowly became a crippling addiction that took hold over Canton. For a rigid society, the crippling Opiate addiction was a moral corruption for the Qing government and forced them to curtail Opium importation in 1780 and then an outright ban in 1796.

https://preview.redd.it/mw9oflprjw4b1.png?width=879&format=png&auto=webp&s=5640d0bc425726fbd471b8dcf8954222afc49fc5
  • Knowing just how devastating the Opium was having on the inhabitants of Canton, as well as how it spread further inland, British merchants kept peddling their drug. Older ships with larger hulls were converted into floating warehouses and parked just outside of navigable waters. Once set up, Opium smugglers would pull up, purchase the Opium and avoid any oversight by the Chinese government to prevent the sale of the drug. Following their mother country, American merchants started to sell Turkish Opium, an inferior variety, at a much cheaper rate leading to drug peddling competition with more and more tons of Opium being sent into China. This drove down the price of Opium considerably which ultimately increased the demand.
    • This demand eventually led to reversal of trade, meaning that more silver was leaving China to pay for Opium than the British were using to pay for Chinese goods. American and European traders could show up in Canton with holds full of Opium, sell it off for a profit, and then make a tidy silver profit to bring back to Europe. Likewise the importation of cheap machine-made cotton, furs, clocks, and steel into China driving down domestic profits.

Let’s Look at the Drugs a Bit


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Stepping away from the history a bit, let’s introduce the Family. Okay so we understand how pain is sent to the brain and how it modulates but there is so much more to the mu Opioid Receptor and that’s not the only kind of Opioid receptor that we have. The two most clinically useful receptors are the Mu and Kappa Opioid Receptors (KOR) because they result in analgesia but there is a Delta Opioid Receptor (DOR) that is worth mentioning. The majority of the Opiates that we know and love are Mu agonists but there are some very interesting Kappa agonists that are worth mentioning as well.

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  • Above is a chart that shows the binding affinities of select Opiates to the Mu receptor. The smaller the number is, the more tightly they bond. Now affinity is different than potency—potency is a measure of how much drug (in g) is required to produce the same effect. So even though morphine has a higher affinity than fentanyl, fentanyl has a MUCH more potent effect (which is why it can be so dangerous, you only need a little). Now many of the opiates cause the same effect so I want to spend more time on what makes them all so different:
  • First up we have the 5-Ring Morphinians which are derived from the natural product Morphine. These structures have 5 component parts: an aromatic benzene ring (A), a completely saturated bridge ring (B), a partially unsaturated ring with an alcohol attachment (C), a piperidine heterocycle above the rest of the structure (D) and finally a ether linkage between the top and bottom of the structure to keep it fairly rigid (E). Truthfully we are only going to focus on two locations—firstly the top alcohol (red circle) can be methylated to form Codeine, a natural Prodrug of Morphine. A Prodrug is one that is biologically inactive but goes through an initial metabolism once ingested that makes it active.

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  • In fact it’s this initial metabolism of Codeine that makes it very interesting. In order for Codeine to exert any pain relief it needs to be converted to Morphine which actually exerts the desirable properties. This is done by the liver enzyme CYP2D6 which is a pretty minor pathway for Codeine—only about 10% of the Codeine is actually converted to Morphine to have some action. Because of this 2D6 dependent pathway we have to be careful about administering drugs that might inhibit the 2D6 pathway because that would mean we are preventing codeine from being active. Drugs like Fluoxetine (Prozac) and Paroxetine (Paxil) are strong 2D6 inhibitors and so if we administered Codeine to someone taking this drug they’d never get any benefit from the Codeine. In addition there are genetic/ethnic differences that pharmacists can account for such as 2D6 activity. If you are someone with very little 2D6 activity then you would also not convert Codeine to Morphine and thus get no action from the drug—this may be a reason why some people say Codeine doesn’t work for them. Another reason could be that they are Rapid Metabolizers and quickly convert the Codeine to Morphine and thus get a massive hit quickly after ingestion—in that cause you’d need a much smaller dose than another person for the same effect.

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  • A different drug that is the opposite of Codeine is Hydromorphone (Dilaudid) which has a Ketone on ring C. This ketone and the lack of the double bond on this ring increases the lipophilicity of the drug and increases its ability to penetrate into the brain and thus have a greater effect. In fact Hydromorphone is 5-10x more potent than Morphine due to its greater ability to penetrate into the brain and increased receptor affinity for the mu receptor. Because the A ring OH is not capped with a methyl group, we don’t need to rely on 2D6 to metabolize Hydromorphone into an active drug form which again increases the activity of this drug compared to Codeine.
  • So combine these two structural changes—the capped OH on ring A as seen in Codeine and the increased affinity found with the ketone in Hydromorphone and we get Hydrocodone (Norco, Lorcet). Well in this case you’d get a drug that has very good affinity for the mu receptor (better than codeine) BUT is still reliant on the small 2D6 pathway for activation (worse than morphine). In this regard only about 10% of Hydrocodone is active at a time. We can see this effect in the relative doses for equivalent effect: to match the effect of 30mg of Morphine, we’d need only 7.5mg of Hydromorphone (more active) but need 200mg of Codeine (less active).

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  • This brings us to our last drug of this class, Oxycodone which has a special OH group found on Ring B. What you’ll notice is that Oxycodone has that capped OH on ring A so it requires metabolism through 2D6 just like Codeine and Hydrocodone. When it is uncapped it becomes Oxymorphone which has 3 times as much effect as Morphine BUT that extra OH makes Oxycodone an exclusive Mu receptor agonist. Unlike the other drugs which may go to other receptors causing side effects (more on this later).

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  • Next up I want to look at some Mu opioid receptor Antagonists or those than inhibit the function of the opioid receptor. Looking at the first two drugs, Naloxone and Naltrexone, we can see that they have the structure similar to Hydromorphone so they would have incredible brain penetration and affinity for opioid receptors BUT they contain that funky Nitrogen tail. Now normally there is a short methyl tail that is required for the function of Morphine but by adding a bulkier tail the drug is able to fit inside the receptor but prevent activation. What’s most important about these two drugs is that they have much more affinity for the receptor than other opiates. We can see this effect in the graph above: when no Naloxone is present, Fentanyl occupies the opiate receptor about 75% of the time. But as soon as Naloxone is administered that number drops swiftly (within minutes)--this is because Naloxone has a higher affinity for sitting in the receptor than Fentanyl. Think of it like the bully Naloxone coming up and pushing the poor defenseless Fentanyl off the swings so the bully can play on it (except in this instance Fentanyl is causing an overdose and we need to save someone’s life).

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  • Buprenorphine is similar but it is a Partial Agonist instead of being a full antagonist. Buprenorphine is not a 5-ring Morphinian byt a 6-ring Oripavine that has a few different modifications. The biggest additions is that it has the bulky Nitrogen tail found in full Antagonists but it has this funky C ring tail which fights the antagonism. The result is a tug of war between the antagonism of the Nitrogen tail and the agonism of this new C-ring tail resulting in Partial agonism—so if you took Buprenorphine you’d notice a markedly decreased pain relieving ability but importantly there is a ceiling effect, its much harder to overdose on Buprenorphine than other full agonists. In addition in the second graph we can see that Buprenorphine has the greatest affinity for the receptor than our other agonists which prevents someone from taking a more potent opiate while taking Buprenorphine. In this case the bully is already sitting on the swing and scaring away the other kids thus preventing them from having a turn (and potentially causing an overdose). This does mean that if someone was taking a more potent drug (like Fentanyl) and then took Buprenorphine, it would cause withdrawal just like Naloxone or Naltrexone.

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  • Speaking of withdrawal, let’s take a look at how that happens. Remember that the pain signal is caused by the activation of AMPA and NMDA receptors from the peripheral nerve. AMPA is a type of receptor called a G-Protein Coupled Receptor or GPCR which in this case is linked to an Excitatory G-protein which leads to the activation of the nerve. When AMPA is activated, the G-protein (Ga) activates an enzyme called Adenylate Cyclase (AC) which increases the production of pro-activity cAMP—or in simpler terms—when AMPA is activated, it leads to an increase in levels of pro-pain molecule cAMP. The Opioid receptor is also a GPCR but it is linked to an inhibitory G-protein which prevents the action of Adenylate Cyclase and thus leads to a decrease in cAMP levels. So Opiates prevent pro-pain cAMP signaling from continuing.
    • In the second graph we can see how tolerance forms. Initially (A), Adenylate Cyclase and cAMP levels are not affected by having opiates even though their ability to push along the pain signal is blocked. After a few hours, the leftover cAMP is degraded and cAMP levels start to drop significantly (B). In response to these levels going down, the activity of Adenylate Cyclase starts to increase and increase (C) which raises the level of cAMP. This rise in Adenylate Cyclase activity opposes the action of the opiate which necessitates the need for increased doses of Opiates and is why tolerance forms. As sustained inhibition of Adenylate Cyclase continues, the body upregulates Adenylate Cyclase activity to create more cAMP and to combat this we increase the dose.
    • Now what if after years of taking an Opiate we suddenly administer Naloxone, an Opiate antagonist. Well after weeks to months of taking an Opiate, the level of Adenylate Cyclase activity is WAY above baseline. When you administer the antagonist, suddenly Adenylate Cyclase is able to produce a TON of cAMP that normally is blocked which leads to a MASSIVE amount of downstream signaling. The result is intense nausea and vomiting, stomach cramps, fever, anxiety, insomnia, and cravings. Thankfully the withdrawal process ends after about 72 hours but is one of the worst experiences someone can go through which is why proper down-tapering of Opiates is extremely important.

A Change in Trade Policy


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Oh, you’re still here. Neat! So by the 1820s the Qing dynasty was running into many problems regarding Opium. Firstly they needed the Opium taxes to fund their efforts to put down the White Lotus Rebellion and retain power. But after almost 30 years of trade the effects on Chinese communities could not be ignored along with local officials operating under the imperial trade department, the Hong, profiting from bribes to allow Opium. Regardless of initial efforts things were getting out of hand for the Qing government. In 1800, about 4000 chests of Opium or 560,000 pounds entered the country but by 1830 that number exploded to 20,000 chests or about 3 million pounds. But more than the amount of Opium actually entering the country was the incessant rudeness of the British government to open trade.
  • One of the “problems” for the British traders was how clamped down trade was with China. By 1800 all trade was limited to just Canton and the Hong was a strict master of trade. Foreigners were not allowed to appeal decisions made by the Hong and only Chinese traders could sell goods further inland than Canton. Traders chafed against this extreme oversight and sent hundreds of letters to the Hong requesting special dispensations which were summarily denied. Things changed significantly in 1834 when the Chinese trade was de-monopolized away from the East India Company allowing any private trader to get involved in the Eastern trade.

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  • In August of 1834, the British sent Lord William John Napier to Macau as superintendent of Chinese trade with the explicit order to follow all Chinese regulations. Thinking he knows best, Napier decided that the restrictive Chinese trade system was too restrictive and sent a letter to the Viceroy of Canton. This was unheard of—NO foreign traders were allowed to speak directly with Chinese officials and the Viceroy refused to accept it. So why not double down by ordering two British ships to BOMBARD two Pearl River forts as a show of force? Luckily Napier died of Typhus almost directly after else it would have resulted in a full blown war.
  • In 1839 the Qing government appointed Lin Zexu as the Opium czar to completely eradicate the Opium trade from China. Lin banned the sale of Opium in China completely, set up rehabilitation centers for those affected by the drug, and put addicts to work to distract them while detoxing. Lin demanded that all Opium supplies must be surrendered to Qing authorities and any Chinese citizen disobeying the order would be punishable by death. He even went as far as closing the Pearl River Channel, trapping British traders in Canton and seizing their Opium warehouse stockpiles.
  • The replacement for Napier was Admiral Sir Charles Elliot who protested the seizure of the Opium stockpile but knew that they could do nothing. He ordered all Opium ships to flee and prepare for battle which caused Lin Zexu to beseige a group of traders inside a Canton warehouse. Elliot convinced the traders to cooperate with the Chinese government and surrender their stock, saying that the British government would compensate for the lost Opium (which he had no authority to do). During April and May 1839 the British (and American) traders to surrender 20,000 chests of Opium which was burned for three days outside Canton. Following the burning, trade resumed to normal except no more Opium was allowed. Like many other instances of the government removing legitimate sale of a drug, the black market increased markedly.
  • In July 1839 a new scandal rocked the British-Chinese trade system; two British sailors became drunk and beat a man death outside of his village. In response, Superintendent Elliot arrested the two men and paid compensation to the villager’s family for the loss of the man but Elliot refused to hand over the sailors to the Qing government. Lin Zexu saw this as a blatant disregard for Chinese law—afterall traders needed to understand that they can’t just come to China and violate Chinese law as they saw fit. Elliot offered to hold a trial on a British ship in front of Chinese officials to show that the men would not get off free. This incident would start the smoldering.
    • On September 4th, Elliot sent two ships to Kowloon to buy food and provisions from Chinese peasants. While approaching the harbor, three Chinese war junks gave permission to the two British ships to trade but that permission was rescinded by the commander of Kowloon fort. Elliot fumed against the slight and said that if the British were not allowed to trade by 3pm, he would fire on the fort. 3pm passed and the British opened fire on the fort causing the Chinese junks to return fire. The fighting continued for 7 hours until nightfall and Elliot had to prevent the British officers from pressing the attack, thus ending the Battle of Kowloon. Having driven off the Chinese ships, the British purchased the supplies they needed while the Kowloon commander claimed that both ships were sunk and 50 British sailors killed.
    • The reaction in Britain was about as much as you expect. Prime Minister Palmerston sent out letters to the Governor General of India to prepare marines to invade China and another letter to the Chinese Emperor telling him that Britain would send a military force. He sent a letter to Superintendent Elliot to set up a blockade on the Pearl River and capture Chusan Island. He also instructed Elliot to accomplish the following objectives:
      • Demand the respect as a British envoy from the Qing Government.
      • Secure the right for British law to be doled out on British subjects
      • Get recompense for destroyed British property, especially the illegal drugs that they destroyed
      • And most important, End the Canton System thus opening up China to free trade for the first time, ever.
Alright this is where we will leave things off for now, on the brink of war with China. Stay tuned!
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2023.06.09 04:14 alpha_beta_marigold Any advice for road trips? Is this a bad idea?

Hi everyone, I got Covid about four months ago, and have been bedridden or homebound since then. I’ve been feeling a bit better over the last month or so and have been able to get out of bed most days and have meals with my family.
We usually spend summers at a family cabin on a lake. I really want to go again this year, but it’s a long drive: about 15 hours. Once I get there, I know I will be very comfortable and happy. But I’m afraid the trip will give me a major crash. Would love to get other people’s advice and perspective on this.
My plan is to turn the backseat of a king cab truck into a bed and ride back there. We did a test drive and it was very comfortable; I could almost fully extend my legs. We would break it up into three days and do five hours of driving per day and I could rest in a quiet hotel room the rest of the time.
However, there’s no way of getting around noisy public bathrooms, the stimulus of being out in the world, and the walk in and out of hotels. Furthermore, driving is noisy and jostles your body around a lot.
There’s nothing that I want more than to relax in a lakeside cabin for five weeks. And my family really needs it too. But I have to admit I’m apprehensive. I’ve had a number of really bad crashes that have left me barely able to walk or talk. I don’t want to risk that again.
Would love any advice, or to hear other people’s experience with these sorts of things!
My main symptoms are heavy fatigue and noise sensitivity. I’ve also got POTS (not as bad as others) and occasional headaches.
submitted by alpha_beta_marigold to covidlonghaulers [link] [comments]